Trazodone has a hidden risk that can make some patients more depressed.
This isn’t about bipolar disorder or antidepressant-induced mania.
It’s about a metabolite, says Chris Aiken, MD.
Can Trazodone be used to treat bipolar disorder?
Uses in Bipolar Disorder
Trazodone may be used to treat the depressive symptoms of bipolar disorder, or it may be used to help with insomnia.
Can trazodone make you manic?
Of note, these mania events can be well-controlled with cessation or reduction of trazodone, administration of haloperidol, or adding mood stabilizers. The symptom of insomnia could be secondary to depression, or a trigger of manic episode, or even an initial manifestation of an evolving manic episode.
What are the side effects of trazodone?
Common side effects of trazodone include:
- Muscle ache.
- Nausea, vomiting, loss of appetite, or stomachache.
- Constipation or diarrhea.
- Loss of interest in sex (erectile dysfunction in men)
- Dizziness or loss of balance.
- Dry mouth or dry eyes.
- Numbness, burning, or tingling sensations.
Can trazodone cause psychosis?
It is important to suspect trazodone as a cause of auditory hallucinations. It is important to discontinue trazodone to treat trazodone-induced auditory hallucinations. Antipsychotic drugs can partially ameliorate such antidepressant-induced hallucinations, but antidepressant discontinuation is essential.